Genetics and inflammatory profile in tobacco dependence-Reference-Cited by-同舟云学术

Genetics and inflammatory profile in tobacco dependence

Published:2019-10-01 Issue:2 Volume:68 Page:91-96
ISSN:2247-059X
Container-title:Pneumologia
language:en
Short-container-title:

Author:

Eugenia Budin Corina¹²,Rajnoveanu Ruxandra¹,Bordea Ioana Roxana³,Marginean Corina²,Domokos Bianca¹,Dantes Elena⁴,Adina Todea Doina¹

Affiliation:

1. Department of Pneumology, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj Napoca , Romania

2. Clinical County Hospital Targu Mures, Pneumology , Targu Mures Romania

3. Department of Oral Rehabilitation, Iuliu Hateganu University of Medicine and Pharmacy, Oral Health and Dental Office Management , Cluj Napoca , Romania

4. Department of Pneumology, Faculty of Medicine, “Ovidius” University Constanta , Constanţa , Romania

Abstract

Abstract The state of health of the population is determined by a set of factors belonging to human biology, environment, behaviors, and the health system (preventive, curative, and rehabilitative). Any of these factors can alter both individual and community health. The primary reason for tobacco dependence is nicotine addiction. Dopamine is released from the neurons located in the mesolimbic system. Nicotine stimulates the release of dopamine from these receptors. The genetic determination of nicotine dependence is determined by the subtypes of nicotine acetylcholine receptors (nAChRs) and conditioned by chromosome mutations at chromosomes 15q25.1, 8p11.21 or 20q13.12-q13.32. Low-amplitude systemic inflammation is demonstrated in all smokers and is confirmed by elevated levels of C-reactive protein, fibrinogen, Interleukin-6, and increased leukocyte levels. Moreover, coagulation and endothelial function markers such as hematocrit, plasma or blood viscosity, D-dimers, circulating adhesion molecules, tissue plasminogen activator, have also modified values in smokers.

Publisher

Walter de Gruyter GmbH

Link

https://www.sciendo.com/pdf/10.2478/pneum-2019-0020

Reference33 articles.

1. European Smoking Cessation Guidelines and Quality Standards – European Network [Internet]. [cited 2018 May 10]. Available from: http://ensp.org/wp-content/uploads/2016/12/ENSP-ESCG_FINAL.pdf

2. WHO. WHO report on the global tobacco epidemic 2015 [Internet]. WHO. [cited 2018 Mar 22]. Available from: http://www.who.int/tobacco/global_report/2015/en/

3. WHO. Adolescents: Health risks and solutions [Internet]. WHO. [cited 2018 Mar 22]. Available from: http://www.who.int/mediacentre/factsheets/fs345/en/

4. Hedman L, Andersson M, Stridsman C, Rönmark E. Selection bias in participation in a smoking prevention program among teenagers. European Respiratory Journal. 2014;44(Suppl. 58): P1125.

5. OECD/EU. Health at a Glance: Europe 2018: State of Health in the EU Cycle Paris: OECD Publishing; 2018 Available from: https://doi.org/10.1787/health_glance_eur-2018-en

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Is the pulmonary microbiome involved in lung cancer pathophysiology?;Acta Marisiensis - Seria Medica;2022-09-01