Author:
Framski Grzegorz,Wawrzyniak Dariusz,Jahnz-Wechmann Zofia,Szymanska-Michalak Agnieszka,Kraszewski Adam,Barciszewski Jan,Boryski Jerzy,Stawinski Jacek
Abstract
Several ribonucleoside analogues with modifications in the nucleobase and sugar moiety have been screened for anti-glioma activity in T98G glioma cell line using cervical (HeLa) as a reference human malignant cell, and lung fibroblast (MCR-5) as a non-cancerous reference cells. Among the investigated compounds, ribonucleosides containing 6-chloropurine (3), 7-guanine (5) and a pyrrolopyrimidine (18) as nucleobases, show promising anti-glioma activity with good selectivity indices, and can be considered as lead structures for further anti-cancer studies.
Publisher
Polskie Towarzystwo Biochemiczne (Polish Biochemical Society)
Subject
General Biochemistry, Genetics and Molecular Biology
Cited by
6 articles.
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