SIGNIFICANCE OF CHANGES IN MYOCARDIAL ENZYMES IN CHILDREN WITH CONGENITAL HEART DEFECTS

Abstract

Introduction. In young children, CHD can occur with disruption of the energy supply of the myocardium and tissue homeostasis. To assess its condition, biochemical indicators are used that reflect various links of the pathological process, both in the whole body and in the myocardium. Purpose of the study: This paper presents diagnostically significant indicators of myocardial damage in young children with congenital heart defects. Material and methods. 150 children with congenital heart disease aged 2 months to 3 years were hospitalized in the pediatric cardio-rheumatology department of the State Institution "National Medical Center" (Tajikistan). They were under observation for the period from 2008 to 2018, and 30 children comprised comparison groups. The structure of defects was represented by: defects of the interventricular (VSD) (50) and interatrial septal (ASD) (50), tetralogy of Fallot (TF) (50). All children underwent clinical-instrumental, laboratory and biochemical research methods: ECG, echocardiography, radiography, troponin-T, MB fraction (MB-CPK), LDH, ALT, AST. Results. Clinical manifestations of cardiac dysfunction in children depended on the type of defect, severity, presence or absence of heart failure. Elevated enzymes AST, LDH, MB-CK and troponins in children with congenital heart disease show the state of the cardiovascular system in congenital heart defects, being markers of myocardial dysfunction. The consequence of chronic heart failure is an increase in the level of AST in children with circulatory disorders of 2 A-B degrees. The degree of myocardial damage in children with CHD allows us to assess the activity of CPK-MB and troponin I in a comprehensive assessment of clinical and functional research methods Conclusions. In children with CHD, there is an increase in the enzymes CF-CF, LDH and troponin I, which are the most significant in the diagnosis of markers of myocardial dysfunction that determine myocardial damage. The consequence of chronic heart failure is an increase in the level of AST in children with circulatory disorders of 2 A-B degrees