Sinonasal diffuse large B-cell lymphoma: own clinical observation and literature review

Author:

Mingalimov M. A.1ORCID,Baryakh E. A.2ORCID,Kochneva O. L.3ORCID,Misyurina E. N.1ORCID,Polyakov Yu. Yu.1ORCID,Zhelnova E. I.1ORCID,Yatskov K. V.3ORCID,Makeshova A. B.1ORCID,Tolstykh T. N.1ORCID,Chudnova T. S.1ORCID,Ivanova D. D.3ORCID,Lebedev D. V.4ORCID,Zotina E. N.1ORCID,Gagloeva D. E.1ORCID,Beregov M. M.5ORCID,Mamatturdiev E. A.6ORCID,Samsonova I. V.3ORCID,Lysenko M. A.3ORCID

Affiliation:

1. City Clinical Hospital No. 52, Moscow Healthcare Department; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

2. City Clinical Hospital No. 52, Moscow Healthcare Department; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University); Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia; N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

3. City Clinical Hospital No. 52, Moscow Healthcare Department

4. State Scientific Center of the Russian Federation – A.I. Burnazyan Federal Medical Biophysical Center, Federal Medical and Biological Agency

5. Federal Center of Brain Research and Neurotechnologies, Federal Medical and Biological Agency

6. Russian University of Medicine, Ministry of Health of Russia

Abstract

Diffuse large B-cell lymphoma is the most common immunomorphological variant of lymphoma in adults. Extranodal lesions are observed in a third of patients at the disease onset. The organs most often involved are the gastrointestinal tract, testicles, bones, thyroid gland, and skin. Primary involvement of the nasal cavity and paranasal sinuses occur extremely rarely and cause diagnostic and therapeutic difficulties.The article demonstrates a rare clinical case of newly diagnosed diffuse large B-cell lymphoma with sinonasal tract involvement. It took 6 months to verify the final diagnosis. At the moment, the induction stage of treatment for diffuse large B-cell lymphoma continues, the achieved complete metabolic response is maintained.

Publisher

Publishing House ABV Press

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