CHANGES IN THE FACTORS OF NON-SPECIFIC RESISTANCE IN PATIENTS WITH ISCHEMIC HEART DISEASE

Abstract

Ischemic heart disease is the most common form of heart disease.CHD occurs as a result of atheromatous changes in the vessels that supply the heart.It is the atheromatous changes in the vessels that result from decreased myocardial perfusion, which causes angina due to ischemia and can lead to myocardial infarction (MI) and/or heart failure.It is one of the leading causes of death in the world. Given that coronary heart disease is a medical and social problem today, it is important to study the diagnosis and prognosis of the course of this pathology. The refore, there is a need to find new sensitive markers for early diagnosis of this pathology. In patients with cardiovascular diseases, the functional state of the cells of the nonspecific immunity of neutrophils often depends on the form of the disease and the severity of the course, and early detection of changes in chemotaxis of neutrophils can help to more accurately assess the risk of infectious complications. Study of factors of the non-specific link of immunity in patients with coronary heart disease. Study of factors of non-specific resistance, namely determination of indicators of phagocytic number, phagocytic index, number of active phagocytes, absolute index of phagocytic activity, percentage of HST-positive neutrophils, detection of cationic lysosomal proteins with calculation of cytochemical coefficients, bactericidal activity of neutrophils (BAN) was performed in 30 patients with coronary artery disease. The control group consisted of 30 healthy age- and gender-matched volunteer donors. Thus, it was established that in patients of the group of patients with coronary artery disease, in comparison with the indicators of the control group, in addition to the decrease in phagocytic activity and activation of the redox function, there is a decrease in the number of cationic lysosomal proteins and the bactericidal activity of NG.