Severe Gastrointestinal Disorder Due to Capecitabine Associated with Dihydropyrimidine Dehydrogenase Deficiency: A Case Report and Literature Review

Author:

Hagiwara Yuya1,Yamamoto Yoshiyuki1,Inagaki Yuki2,Tomisaki Reina1,Tsuji Miki1,Fukuda Soma1,Fukuda Satoshi1,Onoda Tsubasa1,Suzuki Hirosumi1,Niisato Yusuke1,Tange Yoshitaka1,Ikeda Naoya2,Yamada Keiichi2,Kobayashi Mariko1,Akutsu Daisuke1,Yamada Takeshi1,Moriwaki Toshikazu1,Narasaka Toshiaki1,Suzuki Hideo1,Tsuchiya Kiichiro1

Affiliation:

1. Department of Gastroenterology, Faculty of Medicine, University of Tsukuba, Japan

2. Department of Gastrointestinal Surgery, Tsukuba Medical Center Hospital, Japan

Publisher

Japanese Society of Internal Medicine

Subject

General Medicine,Internal Medicine

Reference42 articles.

1. 1. Lu Z, Zhang R, Diasio RB. Purification and characterization of dihydropyrimidine dehydrogenase from human liver. J Biol Chem 267: 17102-17109, 1992.

2. 2. Milano G, Etienne MC. Dihydropyrimidine dehydrogenase (DPD) and clinical pharmacology of 5-fluorouracil. Anticancer Res 14: 2295-2297, 1994.

3. 3. Matsumoto A, Fujita T, Ozaki T, et al. Dihydropyrimidine dehydrogenase deficiency with severe adverse events caused by XELOX+Bevacizumab. Jpn J Gastroenterol Surg 47: 734-739, 2014 (in Japanese).

4. 4. Chazal M, Etienne MC, Renée N, Bourgeon A, Richelme H, Milano G. Link between dihydropyrimidine dehydrogenase activity in peripheral blood mononuclear cells and liver. Clin Cancer Res 2: 507-510, 1996.

5. 5. Fleming RA, Milano GA, Gaspard MH, et al. Dihydropyrimidine dehydrogenase activity in cancer patients. Eur J Cancer 29A: 740-744, 1993.

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