Severe Gastrointestinal Disorder Due to Capecitabine Associated with Dihydropyrimidine Dehydrogenase Deficiency: A Case Report and Literature Review
Author:
Affiliation:
1. Department of Gastroenterology, Faculty of Medicine, University of Tsukuba, Japan
2. Department of Gastrointestinal Surgery, Tsukuba Medical Center Hospital, Japan
Publisher
Japanese Society of Internal Medicine
Subject
General Medicine,Internal Medicine
Link
https://www.jstage.jst.go.jp/article/internalmedicine/61/16/61_8636-21/_pdf
Reference42 articles.
1. 1. Lu Z, Zhang R, Diasio RB. Purification and characterization of dihydropyrimidine dehydrogenase from human liver. J Biol Chem 267: 17102-17109, 1992.
2. 2. Milano G, Etienne MC. Dihydropyrimidine dehydrogenase (DPD) and clinical pharmacology of 5-fluorouracil. Anticancer Res 14: 2295-2297, 1994.
3. 3. Matsumoto A, Fujita T, Ozaki T, et al. Dihydropyrimidine dehydrogenase deficiency with severe adverse events caused by XELOX+Bevacizumab. Jpn J Gastroenterol Surg 47: 734-739, 2014 (in Japanese).
4. 4. Chazal M, Etienne MC, Renée N, Bourgeon A, Richelme H, Milano G. Link between dihydropyrimidine dehydrogenase activity in peripheral blood mononuclear cells and liver. Clin Cancer Res 2: 507-510, 1996.
5. 5. Fleming RA, Milano GA, Gaspard MH, et al. Dihydropyrimidine dehydrogenase activity in cancer patients. Eur J Cancer 29A: 740-744, 1993.
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