Characterization of gastrointestinal absorption of digoxin involving influx and efflux transporter in rats: application ofmdr1aknockout (−/−) rats into absorption study of multiple transporter substrate-Reference-Cited by-同舟云学术

Characterization of gastrointestinal absorption of digoxin involving influx and efflux transporter in rats: application ofmdr1aknockout (−/−) rats into absorption study of multiple transporter substrate

Published:2014-05-19 Issue:11 Volume:44 Page:1039-1045
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Suzuki Motoya,Komura Hiroshi,Yoshikawa Tomonori,Enya Seiji,Nagao Akemi,Takubo Hiroaki,Kogayu Motohiro

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

http://www.tandfonline.com/doi/pdf/10.3109/00498254.2014.920551

Reference46 articles.

1. XENOBIOTIC AND ENDOBIOTIC TRANSPORTER MRNA EXPRESSION IN THE BLOOD-TESTIS BARRIER

2. Utility of 96 well Caco-2 cell system for increased throughput of P-gp screening in drug discovery

3. Variability in P-Glycoprotein Inhibitory Potency (IC50) Using Various in Vitro Experimental Systems: Implications for Universal Digoxin Drug-Drug Interaction Risk Assessment Decision Criteria

4. Differential Substrate and Inhibitory Activities of Ranitidine and Famotidine toward Human Organic Cation Transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3)

5. The Complexities of Hepatic Drug Transport: Current Knowledge and Emerging Concepts

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The Rat Continuous Intestine Model Predicts the Impact of Particle Size and Transporters on the Oral Absorption of Glyburide;Molecular Pharmaceutics;2022-12-21

2. Predicting Impact of Food and Feeding Time on Oral Absorption of Drugs with a Novel Rat Continuous Intestinal Absorption Model;Drug Metabolism and Disposition;2022-03-26

3. Digoxin absorption decreased independently of P-gp activity in rats with irinotecan-induced gastrointestinal damage;Journal of Pharmaceutical Health Care and Sciences;2021-07-01

4. Drug Transporters: Efflux;Reference Module in Biomedical Sciences;2021

5. Effect of excipients on oral absorption process according to the different gastrointestinal segments;Expert Opinion on Drug Delivery;2020-11-17