Amorphous solid dispersion successfully improved oral exposure of ADX71943 in support of toxicology studies
Author:
Publisher
Informa UK Limited
Subject
Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology
Link
http://www.tandfonline.com/doi/pdf/10.3109/03639045.2012.727829
Reference4 articles.
1. ICH Topic Q3C (R4) Impurities: Guideline for Residual Solvents.
2. Prediction of Aqueous Solubility of Organic Compounds by the General Solubility Equation (GSE)
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3. ADX71943 and ADX71441, novel positive allosteric modulators of the GABA B receptor with distinct central/peripheral profiles, show efficacy in the monosodium iodoacetate model of chronic osteoarthritis pain in the rat;European Journal of Pharmacology;2017-01
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