Comparison of Diltiazem Ointment and Safflower Oil in Reducing the Necrosis of Accidental Flap of Rat

Abstract

Background: This study aimed to compare diltiazem-ointment and safflower oil in reducing the necrosis of accidental rat flaps. Method: We divide 40 mice into four groups. We created a 10 × 3 random flap on the back of rats after washing with ketamine intraperitoneal. The flap was used for these four groups of ointments from two days before surgery to five days after surgery. We used diltiazem ointment in the first group, safflower essential oil in the second group and vaseline in the third group. The fourth group was for control Results: The mean necrosis of the flap was observed in 49% of the vaseline group, 52% of the diltiazem group, 53% safflower essential oil group, and 47% of the control group. The P-value with the independent groups' test was more than 0.05 and confirmed no significant difference between Wistar rat groups. Vaseline, diltiazem, and safflower essential oil did not increase blood flow to the random flap in mice. Conclusions: Diltiazem and safflower did not improve blood flow to the flap. Since this drug has not been used for flaps, it is suggested that further studies be conducted in this field.