Investigation of Clinical Significant Utility of LncRNA-LINC02389 in Patients with Esophageal Squamous Cell Carcinoma

Abstract

Background: The lncRNA-LINC02389 gene is a long non-coding RNA, which has not been an assessed potential role in the pathogenesis of esophageal squamous cell carcinoma (ESCC). Objectives: The purpose of the present survey was to evaluate the lncRNA-LINC02389 gene expression variation in subjects with ESCC. Methods: The present survey was a preliminary investigation performed on seventy-five paired paraffin blocks including tumorous and non-tumorous marginal tissues from subjects with ESCC. After extraction of total RNA and cDNA synthesis, the lncRNA-LINC02389 gene expression change was evaluated using quantitative real-time PCR method. Results: Our data declared that the lncRNA-LINC02389 gene was significantly down-regulated in ESCC tissues compared to the marginal tissues (P < 0.05). In addition, the findings showed a significant association between the lncRNA-LINC02389 gene expression change and tumor differentiation grade (P = 0.003). Conclusions: Our results proposed a possible carcinogenesis character of the lncRNA-LINC02389 gene and may be employed as a prognostic clinical significance in the progression of ESCC.