Comparative Characteristics of Inactivation Agents for HFRS Vaccine Development-Reference-Cited by-同舟云学术

Comparative Characteristics of Inactivation Agents for HFRS Vaccine Development

Published:2018-09-19 Issue:4 Volume:17 Page:26-29
ISSN:2619-0494
Container-title:Epidemiology and Vaccine Prevention
language:
Short-container-title:Epidemiology and Vaccine Prevention

Author:

Kurashova C. C.¹,Ishmukhametov A. A.²,Egorova M. C.¹,Balovneva M. V.¹,Dzagurova T. K.¹,Tkachenko E. A.²

Affiliation:

1. Federal State Budget Institution of Science «Chumakov Federal Scientific Center for Research and Development of Immune-andBiological Products of Russian Academy of Sciences»

2. Federal State Budget Institution of Science «Chumakov Federal Scientific Center for Research and Development of Immune-andBiological Products of Russian Academy of Sciences»$ Sechenov First Moscow State Medical University, of the Ministry of Healthcare of the Russian Federation

Abstract

The results of various methods of Puumala virus inactivation, including ultraviolet rays (UV), β -propiolactone (BPL) and formalin are presented. Immunogenicity of vaccine preparations obtained using these virus inactivation methods did not differ significantly in the experiments on BALB/c mice. Essential advantage of UV and BPL in relation to formaldehyde is the short time of virus inactivation.

Publisher

LLC Numicom

Subject

Infectious Diseases,Public Health, Environmental and Occupational Health,Epidemiology

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