Affiliation:
1. Oncology Chemistry, Pfizer Medicine Design
2. Pharmaceutical Sciences, Pfizer Inc.
Abstract
An efficient one-pot two-step synthesis of 1,4-disubstituted 1,2,3-triazoles from α-ketoacetals and amines is presented. The method does not use metals, azides, or oxidants, and is compatible with a variety of functional groups, including heterocycles, esters, nitriles, and carbamates.
Cited by
16 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Insights into the Efficacy and Binding Mode of 1,4-Disubstituted 1,2,3-Triazoles─A New Class of Agricultural Nitrification Inhibitors;ACS Agricultural Science & Technology;2023-10-03
2. Progress in Synthetic Trends Followed for the Development of 1,2,3-Triazole Derivatives: A Review;Polycyclic Aromatic Compounds;2023-08-22
3. Synthesis and Characterization of Novel 2-(1,2,3-Triazol-4-yl)-4,5-dihydro-1H-pyrazol-1-yl)thiazoles and 2-(4,5-Dihydro-1H-pyrazol-1-yl)-4-(1H-1,2,3-triazol-4-yl)thiazoles;Molecules;2022-12-14
4. 1,2,3-Triazoles;Comprehensive Heterocyclic Chemistry IV;2022
5. Rapid, One-Step Synthesis of α-Ketoacetals via Electrophilic Etherification;The Journal of Organic Chemistry;2021-09-27