Do Calcium and Potassium Levels Influence Ductal Patency in Preterm Infants?

Author:

Cakir Ufuk1ORCID,Tayman Cuneyt1,Buyuktiryaki Mehmet1ORCID,Unsal Handan2,Ozer Bekmez Buse1

Affiliation:

1. Division of Neonatology, Health Sciences University, Zekai Tahir Burak Maternity, Education and Research Hospital, Ankara, Turkey

2. Department of Pediatric Cardiology, Health Sciences University, Zekai Tahir Burak Maternity, Education, and Research Hospital, Ankara, Turkey

Abstract

Abstract Objective We investigated the relationship of serum potassium (K+) and ionized calcium (iCa2+) levels with the persistence of ductus arteriosus. Study Design This retrospective cohort study included infants with birth weight < 1,500 g and gestational age < 32 weeks. Serum K+ and iCa2+ levels at the 1st and 48th hour of life were measured from samples. The difference between the two levels was calculated for both serum K+ (ΔK+) and iCa2+ (ΔCa2+). These values were compared between hemodynamically significant patent ductus arteriosus (hsPDA) and non-hsPDA. Results Of 1,322 hospitalized preterm nonates, 1,196 were included in the study. Mean serum K+ levels at the 1st and 48th hour were higher and iCa2+ levels at the 1st and 48th hour were lower in hsPDA and non-hsPDA, respectively (p < 0.001). Ionized ΔCa2+ (–0.06 ± 0.13 vs. –0.02 ± 0.12 mmol/L) was higher in hsPDA (p < 0.001). Conclusion We demonstrated that serum K+ and iCa2+ level might play a role in ductal constriction.

Publisher

Georg Thieme Verlag KG

Subject

Obstetrics and Gynecology,Pediatrics, Perinatology and Child Health

Reference35 articles.

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