Affiliation:
1. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology
Abstract
A simple and practical approach has been established for the synthesis of 6-benzylphenanthridines from benzylic hydrocarbons and 2-isocyanobiphenyls via C(sp3)–H/C(sp2)–H bond functionalization under metal-free condition. The reaction exhibits good functional group tolerance and delivers the target products in moderate to excellent yields. The preliminary mechanistic investigation revealed that a radical intermediate might be involved in this reaction.
Funder
National Natural Science Foundation of China
Program for New Century Excellent Talents in University
Fundamental Research Funds for the Central Universities
Subject
Organic Chemistry,Catalysis
Cited by
10 articles.
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