Associations of Antimicrobial-Resistant Gram-Negative Bloodstream Infections with Outcomes among Hospitalized Pediatric Patients in the United States-Reference-Cited by-同舟云学术

Associations of Antimicrobial-Resistant Gram-Negative Bloodstream Infections with Outcomes among Hospitalized Pediatric Patients in the United States

Published:2021-07-28 Issue:06 Volume:16 Page:247-254
ISSN:1305-7707
Container-title:Journal of Pediatric Infectious Diseases
language:en
Short-container-title:J Pediatr Infect Dis

Author:

Spaulding Alicen Burns¹^ORCID,Watson David¹^ORCID,Dreyfus Jill²,Heaton Phillip¹,Koutsari Christina³^ORCID,Kharbanda Anupam B.⁴

Affiliation:

1. Children's Minnesota Research Institute, Minneapolis, Minnesota, United States

2. Premier, Inc., United States

3. Antimicrobial Stewardship Program, Children's Minnesota, Minneapolis, Minnesota, United States

4. Pediatric Emergency Medicine, Chief of Critical Care Services, Children's Minnesota, Minneapolis, Minnesota, United States

Abstract

Abstract Objective The aim of this study was to assess the impact of pediatric antimicrobial-resistant gram-negative bloodstream infections (GNBSIs). Methods A retrospective cohort study (2009–2016) was conducted using the Premier Healthcare Database among pediatric admissions with GNBSIs at hospitals reporting microbiology data. Infections for neonates and nonneonates were classified as multidrug resistance (MDR), resistant to one or two antibiotic drug classes (1–2DR), or susceptible. Results Among 1,276 GNBSIs, 266 (20.8%) infections were 1–2DR and 23 (1.8%) MDR. Compared with susceptible GNBSIs, MDR nonneonates had higher mortality and higher costs, whereas 1–2DR neonates had longer stays and higher costs. Conclusions Antimicrobial-resistant GNBSIs were associated with worse outcomes among pediatric hospitalized patients.

Funder

Internal Research Grant Program at Children's Minnesota

Publisher

Georg Thieme Verlag KG

Subject

Infectious Diseases,Pediatrics, Perinatology and Child Health

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0041-1731643.pdf

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