Copper-Catalyzed Coupling of N-Phenoxyacetamides and 2H-Azirines for Synthesis of α-Amino Oxime Ethers-Reference-Cited by-同舟云学术

Copper-Catalyzed Coupling of N-Phenoxyacetamides and 2H-Azirines for Synthesis of α-Amino Oxime Ethers

Published:2023-05-19 Issue:20 Volume:55 Page:3393-3401
ISSN:0039-7881
Container-title:Synthesis
language:en
Short-container-title:Synthesis

Author:

Zhu Yue-Lu¹,Chen Jiao²³,Yan Jie¹,Xu Xiu-Xuan¹,Sun Zong-Yu¹

Affiliation:

1. School of Chemistry and Chemical Engineering, Heze University

2. College of Chemistry & Materials Science, Northwest University

3. The College of Life Sciences, Northwest University

Abstract

AbstractCopper-catalyzed coupling reaction involving N-phenoxyacetamides and 2H-azirines is described, in which N–O and C–N bonds are broken and restructured. This protocol provides an efficient strategy for the highly regioselective synthesis of racemic α-amino oxime ethers. In addition, this strategy can be used to modify natural products and is gram-scale compatible.

Funder

Natural Science Foundation of Shandong Province

Heze University

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Catalysis

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-2096-4223.pdf

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