Organic Base-Mediated Carboxylation of (Hetero)aromatic Compounds Using Supercritical Carbon Dioxide (scCO2)-Reference-Cited by-同舟云学术

Organic Base-Mediated Carboxylation of (Hetero)aromatic Compounds Using Supercritical Carbon Dioxide (scCO2)

Published:2022-07-08 Issue:21 Volume:54 Page:4827-4833
ISSN:0039-7881
Container-title:Synthesis
language:en
Short-container-title:Synthesis

Author:

Govender Thavendran¹^ORCID,Chetty Lloyd C.²^ORCID,Kruger Hendrik G.²^ORCID,Arvidsson Per I.²³^ORCID,Naicker Tricia²^ORCID

Affiliation:

1. Department of Chemistry, University of Zululand

2. Catalysis and Peptide Research Unit, University of KwaZulu Natal

3. Science for Life Laboratory, Drug Discovery & Development Platform & Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet

Abstract

AbstractA straightforward site-selective method for the direct carboxylation of resorcinols (3-hydroxyphenol derivatives), phenols, and indoles is reported. The products were obtained in moderate to high yields using supercritical carbon dioxide as an electrophile and solvent under basic conditions. This method offers solvent and metal free conditions without the cumbersome exclusion of air or water with convenient purification.

Funder

National Research Foundation South Africa

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Catalysis

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1894-9073.pdf

Reference27 articles.

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