Recent Advances in Transition-Metal-Catalyzed Cross-Coupling Reactions of gem-Difluorinated Cyclopropanes

Abstract

AbstractAs a special class of cyclopropanes, gem-difluorinated cyclopropanes have many fascinating properties as a result of the gem-difluoro substitution; thus, their reactions have received much attention from the synthetic chemistry community. Recently, gem-difluorinated cyclopropanes have gradually emerged as a type of novel and unique fluorinated allylic synthon in cross-coupling reactions for the synthesis of monofluoroalkenes. Herein, we briefly summarize recent advances in transition-metal-catalyzed reactions of gem-difluorinated cyclopropanes.1 Introduction2 Palladium-Catalyzed Reactions with Linear Selectivity3 Palladium-Catalyzed Reactions with Branched Selectivity4 Other Metal-Catalyzed Reactions5 Conclusions