A Systematic Review on Secondary Metabolites of Paecilomyces Species: Chemical Diversity and Biological Activity

Author:

Li Xiu-Qi12,Xu Kuo1ORCID,Liu Xin-Min1,Zhang Peng1ORCID

Affiliation:

1. Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao, Peopleʼs Republic of China

2. Graduate School of Chinese Academy of Agricultural Sciences, Beijing, China

Abstract

AbstractFungi are well known for their ability to synthesize secondary metabolites, which have proven to be a rich resource for exploring lead compounds with medicinal and/or agricultural importance. The genera Aspergillus, Penicillium, and Talaromyces are the most widely studied fungal groups, from which a plethora of bioactive metabolites have been characterized. However, relatively little attention has been paid to the genus Paecilomyces, which has been reported to possess great potential for its application as a biocontrol agent. Meanwhile, a wide structural array of metabolites with attractive bioactivities has been reported from this genus. This review attempts to provide a comprehensive overview of Paecilomyces species, with emphasis on the chemical diversity and relevant biological activities of these metabolic products. Herein, a total of 148 compounds and 80 references are cited in this review, which is expected to be beneficial for the development of medicines and agrochemicals in the near future.

Funder

National Natural Science Foundation of China

Agricultural Science and Technology Innovation Program of China

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

Reference81 articles.

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5. The entomopathogenic fungi Isaria farinose (formerly Paecilomyces farinosus) and the Isaria fumosorosea species complex (formerly Paecilomyces fumosoroseus): biology, ecology and use in biological control;G Zimmermann;Biocontrol Sci Technol,2008

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