Balancing Altered Calcium Metabolism with Bone Health in Sarcoidosis-Reference-Cited by-同舟云学术

Balancing Altered Calcium Metabolism with Bone Health in Sarcoidosis

Published:2020-08-10 Issue:05 Volume:41 Page:618-625
ISSN:1069-3424
Container-title:Seminars in Respiratory and Critical Care Medicine
language:en
Short-container-title:Semin Respir Crit Care Med

Author:

Zhou Ying¹,Lower Elyse E.²

Affiliation:

1. Department of Respiratory Medicine, Clinical Research Center, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China

2. Department of Internal Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio

Abstract

AbstractAbnormal calcium metabolism in sarcoidosis patients can lead to hypercalcemia, hypercalciuria, and kidney stones. Hypercalcemia in sarcoidosis is usually due to increased activity of 1α-hydroxylase in macrophages of pulmonary granulomata, resulting in low levels of 25-hydroxyvitamin D and high levels of calcitriol. Vitamin D supplementation may be dangerous for some sarcoidosis patients and is recommended only for those with decreased 25-hydroxyvitamin D and reduced or normal calcitriol level. Diagnosis, treatment of osteoporosis, and maintenance of bone health are complex issues for sarcoidosis patients. An approach to diagnosis and treatment of bone fragility is presented.

Publisher

Georg Thieme Verlag KG

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0040-1713009.pdf

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