Affiliation:
1. Organic Catalysis and Biocatalysis Laboratory - LACOB, Federal University of Grande Dourados-UFGD
2. Foreign Visiting Professor, School of Chemistry and Food, Federal University of Rio Grande-FURG
Abstract
AbstractBuchwald precatalyst (XantPhos Pd-G3) was employed for the first time in a C–S cross-coupling reaction involving 2-(4-bromophenyl)benzothiazole or 5-bromo-2,1,3-benzothiadiazole with various benzenethiols in DMF, K2CO3 as a base, under microwave irradiation at 80 °C, 200 W. Good to excellent yields of the desired products were obtained under microwave conditions. Other significant benefits of this synthetic approach are low catalyst loading, short reaction times, and eco-friendly conditions. Additionally, 29 compounds were successfully synthesized, some of which are new in this protocol.
Funder
Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Subject
Organic Chemistry,Catalysis