Affiliation:
1. Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University
2. Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University
Abstract
Optically pure carboxylic acid segments, which are common key intermediates for the synthesis of naturally occurring bicyclic depsipeptide histone deacetylase inhibitors, have been produced efficiently. The method features the chromatographic separation of two diastereomers, which were formed by direct amide condensation of racemic (3RS,4E)-3-hydroxy-7-mercaptohept-4-enoic acid (rac-Hmh) with chiral amino acids. This approach offers a reliable and practical method for producing optically pure carboxylic acid segments, which can facilitate easier access to important anticancer agents derived from them.
Funder
Ministry of Education, Culture, Sports, Science and Technology of Japan
Subject
Organic Chemistry,Catalysis
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献