Isocyanide-Based MCRs: Straightforward Access to Perfluroalkylated γ-Spiroiminolactones-Reference-Cited by-同舟云学术

Isocyanide-Based MCRs: Straightforward Access to Perfluroalkylated γ-Spiroiminolactones

Published:2018-07-16 Issue:20 Volume:50 Page:4104-4112
ISSN:0039-7881
Container-title:Synthesis
language:en
Short-container-title:Synthesis

Author:

Zhang Hui¹²,Cao Weiguo¹³⁴,Tao Lili¹,Fan Zhenhua¹,Peng Xin⁵,Han Jing¹,He Weimin¹,Chen Jie¹,Deng Hongmei²,Shao Min²

Affiliation:

1. Department of Chemistry, Innovative Drug Research Center, Shanghai University

2. Laboratory for Microstructures, Instrumental Analysis and Research Center of Shanghai University

3. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of S ciences

4. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

5. Qianweichang College, Shanghai University

Abstract

A variety of perfluoroalkyl-substituted γ-spiroiminolactones have been synthesized via a one-pot, three-component cascade reaction in which isocyanides, methyl perfluoroalk-2-ynoates and 1,2-diketones undergo highly regioselective Michael addition, nucleophilic addition and cyclization. This reaction has the advantages of good to excellent chemical yields, operationally simple procedure, and short reaction times.

Funder

National Natural Science Foundation of China

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Catalysis

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0037-1610540.pdf

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