Affiliation:
1. Zhantansi Outpatient, Central Medical District of Chinese PLA General
Hospital, Beijing, China
2. College of Otolaryngology Head and Neck Surgery, Chinese PLA General
Hospital, Beijing, China
Abstract
AbstractThis cohort study evaluated the associations of different treatments with the
prognosis of follicular variant papillary thyroid carcinoma (FVPTC) and
classical papillary thyroid carcinoma (CPTC) patients. The data of 69034 PTC
patients were retrieved from the Surveillance, Epidemiology, and End Results
(SEER) database. The 5-year mortality of CPTC and FVPTC patients receiving
surgery, radiation and combination therapy were compared. The univariable and
multivariable cox proportional risk models explored the associations between
different treatments and the 5-year mortality in CPTC and FVPTC patients. The
5-year mortality of CPTC patients was 2.81% and FVPTC patients was
2.47%. Compared with CPTC receiving lobectomy and/or
isthmectomy, those not receiving surgery were associated with increased risk of
5-year mortality [Hazards ratio (HR)=3.27, 95% confidence
interval (CI): 2.55–4.20] while total thyroidectomy was correlated with
reduced risk of 5-year mortality (HR=0.67, 95%CI:
0.55–0.80). Radioactive iodine (RAI) was linked with decreased risk of
5-year mortality in CPTC patients (HR=0.57, 95%CI:
0.50–0.65). CPTC patients undergoing both surgery and radiation were
related to decreased risk of 5-year mortality compared with those receiving
surgery only (HR=0.55, 95%CI: 0.48–0.63). CPTC patients
receiving neither surgery nor radiation (HR=4.53, 95%CI:
3.72–5.51) or those receiving radiation (HR=1.98, 95%CI:
1.13–3.48) were correlated with elevated risk of 5-year mortality. The
elevated risk of 5-year mortality in FVPTC patients was reduced in those
undergoing RAI (HR=0.63, 95%CI: 0.51–0.76). In
conclusion, combination therapy was associated with decreased risk of 5-year
mortality in CPTC and FVPTC patients, which might provide a reference for the
management of these patients.
Subject
Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,General Medicine,Endocrinology, Diabetes and Metabolism
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