Affiliation:
1. Department of Urology, The Second People’s Hospital of Hefei,
Hefei, China
Abstract
AbstractProstate cancer is a common male cancer with high morbidity and mortality
worldwide. According to current research, the integration of long non-coding RNA
(lncRNAs) and microRNA(miRNAs) can be expressed in a variety of cancers and play
an important role in diagnosis. Based on this, this study explored the clinical
role of lncRNA MAGI2-AS3 (MAGI2-AS3) in prostate cancer. By detecting the
expression levels of MAGI2-AS3 and miR-142-3p, the correlation between the
MAGI2-AS3 expression and the characteristics of clinical data was analyzed. ROC
curve analysis was performed and the area under the ROC curve (AUC) was used to
evaluate the diagnostic value of MAGI2-AS3 in distinguishing prostate cancer
patients from healthy controls. The function of MAGI2-AS3 in prostate cancer
cells was explored through CCK-8 and Transwell assays, and the relationship
between MAGI2-AS3 and miR-142-3p was investigated by luciferase activity assay.
MAGI2-AS3 has descended expression while miR-142-3p has an ascendant one in
prostate cancer serum samples and cells. ROC curve analysis revealed that the
AUC was 0.953 for MAGI2-AS3, with a sensitivity of 91.5% and specificity
of 84.7%. Overexpression of MAGI2-AS3 in LNCaP and PC3 cells suppressed
the biological function of the cell including proliferation capacity, migration
level, and invasion. MAGI2-AS3 was considered a diagnostic biomarker for
prostate cancer patients and inhibited prostate cancer progression by targeting
miR-142-3p.
Subject
Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,General Medicine,Endocrinology, Diabetes and Metabolism
Cited by
12 articles.
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