Affiliation:
1. Laboratory of Asymmetric Synthesis, Chongqing University of Arts and Sciences
2. College of Chemistry and Environmental Engineering, Chongqing University of Arts and Sciences
Abstract
AbstractWe have developed an iron-catalyzed synthesis of pyrrolo[2,1-a]isoquinoline derivatives with tetrahydroisoquinolines, arylacyl bromides, and nitroolefins. Highly functionalized pyrrolo[2,1-a]isoquinolines can be obtained in moderate to good yields through a three-component N-alkylation/oxidative 1,3-dipolar cycloaddition/elimination/aromatization cascade. The obtained products in this study can be easily modified by easy chemical transformations to structurally complex molecules bearing privileged framework.
Funder
National Natural Science Foundation of China
Cited by
8 articles.
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