Efficacy of Continuous Saline Irrigation Therapy for Descending Necrotizing Mediastinitis

Author:

Ohashi Takuya1ORCID,Kawago Mitsumasa1,Hirai Yoshimitsu1,Yata Yumi1,Fusamoto Aya1,Iguchi Hideto1,Nakaya Takahito1,Kiyoi Megumi1,Miyasaka Miwako1,Kawaji Mari1,Fujiwara Yuki1,Nishimura Yoshiharu1

Affiliation:

1. Department of Thoracic and Cardiovascular Surgery, Wakayama Medical University, Wakayama, Japan

Abstract

Abstract Objectives Descending necrotizing mediastinitis (DNM) is a poor prognosis disease. This study aims to examine the patient background and treatment of DNM and to identify more effective treatments for DNM. Methods The patient background and treatment of 11 patients who underwent surgery for DNM between November 2010 and June 2021 were studied. The patients were divided into six patients who underwent continuous saline irrigation (group I) and five patients who did not (group N). The differences in the drainage duration and length of hospital stay between the two groups were retrospectively investigated. Results Eleven patients were treated for DNM: six male and five female, with a median age of 61 years (35–79). Comorbidities included diabetes mellitus in three cases; one patient was administered steroids. The pathways of occurrence were anterior tracheal gap/vascular visceral gap/posterior visceral gap in group I (2/1/2) and group N (0/2/4). Progression was I/IIA/IIB according to Endo's classification in group I (1/1/4) and group N (3/1/1). The mean duration of irrigation was 9.0 ± 3.7 days, and the drainage duration in group I was 17.5 ± 8.2 days, which was significantly shorter than 31 ± 13.6 days in group N (p < 0.048). The hospital stays in group I was 29.3 ± 8.4 days, which was significantly shorter than that in group N (68 ± 27.1 days; p < 0.015). Conclusions Irrigation therapy significantly shortened the drainage duration and hospital stay. Irrigation is a useful treatment for DNM.

Publisher

Georg Thieme Verlag KG

Subject

General Medicine

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