Chronic Pulmonary Aspergillosis as a Considerable Complication in Post-Tuberculosis Lung Disease

Author:

Neuböck Matthias J.12,Günther Gunar34,Barac Aleksandra5,Davidsen Jesper R.67,Laursen Christian B.67,Agarwal Ritesh8,Sehgal Inderpaul S.8,Lange Christoph9101112,Salzer Helmut J.F.1213,

Affiliation:

1. Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine 4 - Pneumology, Kepler University Hospital, Linz, Austria

2. Medical Faculty, Johannes Kepler University Linz, Linz, Austria

3. Department of Pulmonology and Allergology, Inselspital, Bern University Hospital, Bern, Switzerland

4. Department of Medical Sciences, Faculty of Health Sciences, University of Namibia, Windhoek, Namibia

5. Clinic for Infectious and Tropical Diseases, University Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia

6. Department of Respiratory Medicine, Pulmonary Aspergillosis Centre Denmark, Odense University Hospital, Odense, Denmark

7. Department of Clinical Research, Odense Respiratory Research Unit, University of Southern Denmark, Odense, Denmark

8. Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India

9. Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany

10. German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany

11. Respiratory Medicine and International Health, University of Lübeck, Lübeck, Germany

12. Baylor College of Medicine and Texas Children's Hospital, Global Tuberculosis Program, Houston, Texas

13. Ignaz-Semmelweis-Institute, Interuniversity Institute for Infection Research, Vienna, Austria

Abstract

AbstractPost-tuberculosis lung disease (PTLD) has only recently been put in the spotlight as a medical entity. Recent data suggest that up to 50% of tuberculosis (TB) patients are left with PTLD-related impairment after completion of TB treatment. The presence of residual cavities in the lung is the largest risk factor for the development of chronic pulmonary aspergillosis (CPA) globally. Diagnosis of CPA is based on four criteria including a typical radiological pattern, evidence of Aspergillus species, exclusion of alternative diagnosis, and a chronic course of disease. In this manuscript, we provide a narrative review on CPA as a serious complication for patients with PTLD.

Publisher

Georg Thieme Verlag KG

Reference104 articles.

1. Post-tuberculosis lung disease: clinical review of an under-recognised global challenge;B W Allwood;Respiration,2021

2. Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management;D W Denning;Eur Respir J,2016

3. Global burden of chronic pulmonary aspergillosis complicating sarcoidosis;D W Denning;Eur Respir J,2013

4. CPAnet registry-an international chronic pulmonary aspergillosis registry;C B Laursen;J Fungi (Basel),2020

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