Recognition of Symmetry as a Powerful Tool in Natural Product Synthesis

Author:

Schindler Corinna S1,Cala Lara2,Gaviria Mario A1,Kim Scott L1,Vogel Trenton R1

Affiliation:

1. Chemistry, University of Michigan College of Literature Science and the Arts, Ann Arbor, United States

2. Chemistry, University of Michigan, Ann Arbor, United States

Abstract

The design of concise and efficient synthetic strategies to access naturally occurring, pharmaceutically active complex molecules is of utmost importance in current chemistry. It not only enables rapid access to these molecules and their analogues but also provides sufficient quantities for their biological evaluation. Identification of any symmetric or pseudosymmetric synthetic intermediates upon retrosynthetic bond disconnection of the target molecule holds the promise to significantly streamline the route towards the compound of interest. This review will highlight recent examples of successful natural product syntheses reported within the past five years that benefited from the recognition of symmetry elements during the retrosynthetic design.

Funder

Alfred P. Sloan Foundation

Camille and Henry Dreyfus Foundation

National Science Foundation

David and Lucile Packard Foundation

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Catalysis

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