Affiliation:
1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
2. National Research University Higher School of Economics
Abstract
AbstractFive-membered heterocyclic N-oxides attract special attention due to their significant potential applications in medicinal chemistry and advanced materials science. In this regard, novel methods for their synthesis and functionalization are in constant demand. In this short review, recent state-of-the-art achievements in the chemistry of isoxazoline N-oxides, 1,2,3-triazole 1-oxides and 1,2,5-oxadiazole 2-oxides are summarized. The main routes involving transition-metal-catalyzed and metal-free functionalization protocols along with mechanistic considerations are outlined. The transformations of these hetarene N-oxide rings as precursors to other nitrogen heterocyclic systems are also presented.1 Introduction2 Isoxazoline N-Oxides3 1,2,3-Triazole 1-Oxides4 1,2,5-Oxadiazole 2-Oxides5 Conclusion
Funder
Ministry of Science and Higher Education of the Russian Federation
Subject
Organic Chemistry,Catalysis
Cited by
19 articles.
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5. Green Synthesis of Five-Membered Hetarene N-Oxides: A Designed Approach to the Synthesis of Substituted Chromeno[3,4-c]pyrrole-2-oxides;Synthesis;2023-08-21