Simple and Efficient Synthesis of Highly Functional 2-Oxonicotino­nitriles from 2-Chloronicotinonitriles

Abstract

AbstractA simple strategy for the synthesis of 2-oxo-1,2-dihydropyridine-3-carbonitrile derivatives (2-oxonicotinonitrile, 3-cyanopyridone) in good yields by substituting the halogen atom with an oxime under mild conditions was developed. The proposed approach makes it possible to avoid the problems associated with the hydrolysis of easily modified groups, since the reaction is carried out in the absence of water.