Affiliation:
1. Department of Psychiatry and Psychotherapy, University Medical Center
Rostock, Rostock, Germany
Abstract
AbstractA number of psychiatric disorders are defined by persistent or recurrent
sleep-wake disturbances alongside disruptions in circadian rhythm and
altered clock gene expression. Circadian rhythms are present not only in the
hypothalamic suprachiasmatic nucleus but also in peripheral tissues. In this
respect, cultures of human derived dermal fibroblasts may serve as a
promising new tool to investigate cellular and molecular mechanisms
underlying the pathophysiology of mental illness. In this article, we
discuss the advantages of fibroblast cultures to study psychiatric disease.
More specifically, we provide an update on recent advances in modeling
circadian rhythm disorders using human fibroblasts.
Subject
Pharmacology (medical),Psychiatry and Mental health,General Medicine
Cited by
2 articles.
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