A Highly Efficient Gold(I)-Catalyzed Mukaiyama–Mannich Reaction of α-Amino Sulfones with Fluorinated Silyl Enol Ethers To Give β-Amino α-Fluorinated Ketones-Reference-Cited by-同舟云学术

A Highly Efficient Gold(I)-Catalyzed Mukaiyama–Mannich Reaction of α-Amino Sulfones with Fluorinated Silyl Enol Ethers To Give β-Amino α-Fluorinated Ketones

Published:2017-07-12 Issue:16 Volume:28 Page:2194-2198
ISSN:0936-5214
Container-title:Synlett
language:en
Short-container-title:Synlett

Author:

Yu Jin-Sheng¹,Zhou Jian¹²,Hu Xiao-Si¹,Du Yi³,Liao Fu-Min¹,Ding Pei-Gang¹

Affiliation:

1. Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University

2. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

3. Xinhua Hospital, affiliated to Shanghai Jiaotong University School of Medicine

Abstract

Ph3PAuOTf was identified as a powerful catalyst for the Mukaiyama–Mannich reaction of fluorinated silyl enol ethers with α-amino sulfones. This provides ready access to β-amino α-fluorinated ketones in good to excellent yields.

Funder

National Natural Science Foundation of China

973 program

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0036-1588475.pdf

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