A Novel 18F-Labeling Method for the Synthesis of [18F]-Piperidine-Containing Ligands as Potential PET Radiotracers for σ Receptors

Abstract

We report a novel 18F-labeling method for the preparation of 18F-containing piperidine derivatives. This method is demonstrated on the design and synthesis of 18F-labeled potential PET radiotracers of σ receptors for initial biological evaluations.1 Introduction2 Design and Synthesis of Novel [19F]-3 and [ 19F]-3′ 3 Radiosynthesis of Novel [18F]-3 and [18F]-3′ 4 In vivo Uptake and Pharmacokinetics of [18F]-3 and [18F]-3′ 5 Conclusion