Tranexamic Acid and the Risk of Delirium after Off-Pump Surgery-Reference-Cited by-同舟云学术

Tranexamic Acid and the Risk of Delirium after Off-Pump Surgery

Published:2022-06-06 Issue: Volume: Page:
ISSN:0171-6425
Container-title:The Thoracic and Cardiovascular Surgeon
language:en
Short-container-title:Thorac Cardiovasc Surg

Author:

Hulde Nikolai¹,Zittermann Armin²^ORCID,Deutsch Marcus-Andre²,Gummert Jan F.²,von Dossow Vera¹,Koster Andreas¹

Affiliation:

1. Institute of Anesthesiology and Pain Therapy, Herz- und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen, Nordrhein-Westfalen, Germany

2. Clinic for Thoracic and Cardiovascular Surgery, Herz- und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen, Nordrhein-Westfalen, Germany

Abstract

AbstractWe investigated whether in patients undergoing off-pump coronary artery bypass grafting surgery a single bolus of 1 g tranexamic acid (TXA) impacts the risk of postoperative delirium using the propensity score matching approach. In 2,757 pairs, the risk of delirium was 4.2% (TXA group) and 5.0% (non-TXA group), with a relative risk in the TXA versus the non-TXA group of 0.83 (95% confidence interval: 0.65–1.07; p = 0.16). There was no significant interaction between TXA administration and renal function on the risk of delirium (p = 0.12). Data indicate that a single bolus of 1 g TXA does not increase the risk of delirium in patients undergoing off-pump surgery.

Publisher

Georg Thieme Verlag KG

Subject

Cardiology and Cardiovascular Medicine,Pulmonary and Respiratory Medicine,Surgery

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0042-1745811.pdf

Reference10 articles.

1. Delirium in elderly people;S K Inouye;Lancet,2014

2. Outcome of delirium in critically ill patients: systematic review and meta-analysis;J I Salluh;BMJ,2015

3. Tranexamic acid concentrations associated with human seizures inhibit glycine receptors;I Lecker;J Clin Invest,2012

4. Role of epileptic activity in older adults with delirium, a prospective continuous EEG study;S Sambin;Front Neurol,2019

5. Tranexamic acid and the burden of early neurologic complications in valvular open-heart surgery: a propensity matched analysis in 3227 patients;N Hulde;J Clin Anesth,2021