Author:
Chen Wenteng,Zhang Guolin,Chen Yitong,Zhu Qi,Wang Haiyang,Yu Yongping
Abstract
AbstractAn efficient synthesis of unsymmetrical 2,6-disubstituted pyrazines was developed via a palladium(II)-catalyzed cascade reaction from aminoacetonitriles and arylboronic acids. This transformation involves a C(sp)–C(sp2) coupling followed by an intramolecular C–N bond formation in good to excellent yields.
Funder
Zhejiang Provincial Public Welfare Projects
Subject
Organic Chemistry,Catalysis