Inhibition of ATR acutely sensitizes acute myeloid leukemia cells to nucleoside analogs that target ribonucleotide reductase-Reference-Cited by-同舟云学术

Inhibition of ATR acutely sensitizes acute myeloid leukemia cells to nucleoside analogs that target ribonucleotide reductase

Published:2018-05-22 Issue:10 Volume:2 Page:1157-1169
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Fordham Sarah E.¹,Blair Helen J.¹,Elstob Claire J.¹,Plummer Ruth¹,Drew Yvette¹,Curtin Nicola J.¹,Heidenreich Olaf¹,Pal Deepali¹,Jamieson David¹,Park Catherine¹,Pollard John²,Fields Scott²,Milne Paul³,Jackson Graham H.⁴,Marr Helen J.⁴,Menne Tobias⁴,Jones Gail L.⁴,Allan James M.¹

Affiliation:

1. Newcastle Cancer Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom;

2. Vertex Pharmaceuticals (Europe) Ltd, Abingdon, Oxfordshire, United Kingdom;

3. Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; and

4. Department of Haematology, Freeman Hospital, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, United Kingdom

Abstract

Key Points Loss of ATR signaling is cytotoxic to AML cells in combination with gemcitabine and hydroxyurea via the induction of replication stress. A small molecule inhibitor of ATR in combination with gemcitabine completely eradicates AML in an orthotopic xenograft mouse model.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/2/10/1157/879977/advances015214.pdf

Reference50 articles.

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4. ATR prohibits replication catastrophe by preventing global exhaustion of RPA;Toledo;Cell,2013

5. ATR phosphorylates SMARCAL1 to prevent replication fork collapse;Couch;Genes Dev,2013

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