Apolipoprotein A-I enhances activated protein C cytoprotective activity-Reference-Cited by-同舟云学术

Apolipoprotein A-I enhances activated protein C cytoprotective activity

Published:2020-06-02 Issue:11 Volume:4 Page:2404-2408
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Gleeson Eimear M.¹,Rehill Aisling M.²,Willis Fox Orla²,Ni Ainle Fionnuala³^ORCID,McDonnell Cormac J.²,Rushe Hannah J.²,McCluskey Seán²^ORCID,O’Donnell James S.¹²⁴^ORCID,Preston Roger J. S.¹²^ORCID

Affiliation:

1. National Children’s Research Centre, Our Lady’s Children’s Hospital Crumlin, Crumlin, Dublin, Ireland;

2. Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland;

3. SPHERE Research Group, School of Medicine, University College Dublin, Dublin, Ireland; and

4. St. James’s Hospital, Dublin, Ireland.

Abstract

Key Points High-density lipoprotein and apolipoprotein A-I enhance activated protein C cytoprotective activity. High-density lipoprotein and apolipoprotein A-I significantly increase the rate at which activated protein C degrades cytotoxic extracellular histones.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/4/11/2404/1743387/advancesadv2019001316.pdf

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