Hypomethylating agents in relapsed and refractory AML: outcomes and their predictors in a large international patient cohort

Author:

Stahl Maximilian1,DeVeaux Michelle2,Montesinos Pau3,Itzykson Raphael4,Ritchie Ellen K.5,Sekeres Mikkael A.6,Barnard John D.6,Podoltsev Nikolai A.1,Brunner Andrew M.7,Komrokji Rami S.8,Bhatt Vijaya R.9,Al-Kali Aref10,Cluzeau Thomas11,Santini Valeria12,Fathi Amir T.7,Roboz Gail J.5,Fenaux Pierre4,Litzow Mark R.10,Perreault Sarah13,Kim Tae Kon1,Prebet Thomas1,Vey Norbert14,Verma Vivek9,Germing Ulrich15,Bergua Juan Miguel16,Serrano Josefina17,Gore Steven D.1,Zeidan Amer M.1

Affiliation:

1. Section of Hematology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT;

2. Department of Biostatistics, Yale School of Public Health, New Haven, CT;

3. Department of Medicine, University of Valencia, Hospital Universitario y Politécnico La Fe, Valencia, Spain;

4. Section of Hematology, Saint-Louis Hospital, University Paris 7, Paris, France;

5. Weill Cornell Medicine and New York Presbyterian Hospital, New York, NY;

6. Leukemia Program, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH;

7. Massachusetts General Hospital Cancer Center, Department of Hematology/Oncology, Harvard Medical School, Boston, MA;

8. Department of Malignant Hematology, Moffitt Cancer Center and Research Institute, Tampa, FL;

9. Division of Oncology & Hematology, University of Nebraska Medical Center, Omaha, NE;

10. Division of Hematology, Mayo Clinic, Rochester, MN;

11. Cote d'Azur University, Nice Sophia Antipolis University, Centre Hospitalier Universitaire de Nice, Nice, France;

12. Division of Hematology, University of Florence, Azienda Ospedaliero Universitaria Careggi, Florence, Italy;

13. Department of Pharmacy, Yale New Haven Hospital, New Haven, CT;

14. Department of Hematology, Institut Paoli Calmettes, Marseille, France;

15. Department of Haematology, Oncology and Clinical Immunology, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany;

16. Section of Hematology, Hospital San Pedro Alcántara, Cáceres, Spain; and

17. Section of Hematology, University Hospital Reina Sofia, Cordoba, Spain

Abstract

Key Points In the largest study of HMAs in RR-AML to date, 16% of patients achieved CR/CRi and experienced a median OS of 21 months. Low proliferative disease (peripheral blood blasts <5%) was associated with improved response and OS.

Publisher

American Society of Hematology

Subject

Hematology

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