Enhanced labile plasma iron in hematopoietic stem cell transplanted patients promotes Aspergillus outgrowth-Reference-Cited by-同舟云学术

Enhanced labile plasma iron in hematopoietic stem cell transplanted patients promotes Aspergillus outgrowth

Published:2019-06-05 Issue:11 Volume:3 Page:1695-1700
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Petzer Verena¹^ORCID,Wermke Martin²,Tymoszuk Piotr¹^ORCID,Wolf Dominik³⁴,Seifert Markus¹⁵,Ovaçin Rıdvan¹,Berger Sylvia¹,Orth-Höller Dorothea⁶,Loacker Lorin⁷,Weiss Günter¹⁵^ORCID,Haas Hubertus⁸^ORCID,Platzbecker Uwe²⁹,Theurl Igor¹

Affiliation:

1. Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria;

2. Department of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany;

3. Department of Internal Medicine V, Hematology and Oncology, Medical University of Innsbruck, Innsbruck, Austria;

4. Medical Clinic 3, University Hospital Bonn, Bonn, Germany;

5. Christian Doppler Laboratory for Iron Metabolism and Anemia Research,

6. Division of Hygiene and Medical Microbiology,

7. Central Institute for Medical and Chemical Laboratory Diagnostics, and

8. Division of Molecular Biology, Medical University of Innsbruck, Innsbruck, Austria; and

9. Medizinische Klinik und Poliklinik I, Hämatologie und Zelltherapie, Universitatsklinikum Leipzig, Leipzig, Germany

Abstract

Key Points Serum-enhanced labile plasma iron in patients undergoing allogeneic HSCT is critical for Aspergillus fumigatus growth in vitro. Transferrin iron in serum is inaccessible for A fumigatus, and uptake of iron in the form of eLPI involves fungal siderophores.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/3/11/1695/1631851/advancesadv2019000043.pdf

Reference23 articles.

1. Aspergillus infections in transplant recipients;Singh;Clin Microbiol Rev,2005

2. Non-transferrin bound iron: a key role in iron overload and iron toxicity;Brissot;Biochim Biophys Acta,2012

3. Enhanced labile plasma iron and outcome in acute myeloid leukaemia and myelodysplastic syndrome after allogeneic haemopoietic cell transplantation (ALLIVE): a prospective, multicentre, observational trial;Wermke;Lancet Haematol,2018

4. Non-transferrin-bound iron during allogeneic stem cell transplantation;Sahlstedt;Br J Haematol,2001

5. Iron overload in allogeneic hematopoietic cell transplantation outcome: a meta-analysis;Armand;Biol Blood Marrow Transplant,2014

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