A novel method to generate T-cell receptor–deficient chimeric antigen receptor T cells-Reference-Cited by-同舟云学术

A novel method to generate T-cell receptor–deficient chimeric antigen receptor T cells

Published:2018-03-05 Issue:5 Volume:2 Page:517-528
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Kamiya Takahiro¹,Wong Desmond¹^ORCID,Png Yi Tian¹^ORCID,Campana Dario¹

Affiliation:

1. Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

Abstract

Key PointsNewly designed PEBLs prevent surface expression of T-cell receptor in T cells without affecting their function. Combined with chimeric antigen receptors, PEBLs can rapidly generate powerful antileukemic T cells without alloreactivity.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/2/5/517/880400/advances012823.pdf

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