Molecular features of a large cohort of primary central nervous system lymphoma using tissue microarray

Author:

Villa Diego12ORCID,Tan King L.13,Steidl Christian14,Ben-Neriah Susana1ORCID,Al Moosawi Muntadhar4ORCID,Shenkier Tamara N.2ORCID,Connors Joseph M.12,Sehn Laurie H.12,Savage Kerry J.12,Scott David W.12,Gascoyne Randy D.14,Slack Graham W.14

Affiliation:

1. Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada;

2. Division of Medical Oncology, BC Cancer and University of British Columbia, Vancouver, BC, Canada;

3. Department of Tissue Pathology, Institute for Clinical Pathology and Medical Research, Westmead Hospital, Westmead, NSW, Australia; and

4. Department of Pathology and Laboratory Medicine, BC Cancer and University of British Columbia, Vancouver, BC, Canada

Abstract

Key Points PCNSL has a unique molecular profile distinct from that of systemic DLBCL. BCL6 rearrangements are associated with a poor prognosis in PCNSL.

Publisher

American Society of Hematology

Subject

Hematology

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