Polyphosphate/platelet factor 4 complexes can mediate heparin-independent platelet activation in heparin-induced thrombocytopenia-Reference-Cited by-同舟云学术

Polyphosphate/platelet factor 4 complexes can mediate heparin-independent platelet activation in heparin-induced thrombocytopenia

Published:2016-11-22 Issue:1 Volume:1 Page:62-74
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Cines Douglas B.¹²³,Yarovoi Serge V.¹³,Zaitsev Sergei V.⁴³,Lebedeva Tatiana¹³,Rauova Lubica⁵³,Poncz Mortimer⁵³,Arepally Gowthami M.⁶³,Khandelwal Sanjay⁶³,Stepanova Victoria¹³,Rux Ann H.¹³,Cuker Adam¹²³,Guo Cecilia⁷⁷³,Ocariza Linnette Mae⁸³,Travers Richard J.⁹³,Smith Stephanie A.⁹³,Kim Hugh⁷⁷¹⁰³,Morrissey James H.⁹³,Conway Edward M.⁸³

Affiliation:

1. Department of Pathology and Laboratory Medicine,

2. Department of Medicine, and

3. Faculty of Dentistry,

4. Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA;

5. Division of Hematology, Children’s Hospital of Philadelphia, Philadelphia, PA;

6. Department of Medicine, Duke University School of Medicine, Durham, NC;

7. Faculty of Biochemistry, and

8. Faculty of Medicine and Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada;

9. Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL; and

10. Faculty of Molecular Biology, University of British Columbia, Vancouver, BC, Canada

Abstract

Key Points Polyphosphates form antigenic complexes with PF4 that are recognized by HIT antibodies. Polyphosphate/PF4 complexes released by activated platelets can mediate platelet aggregation by HIT antibodies in the absence of heparin or cell-surface chondroitin sulfate.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/1/1/62/877425/advances000877.pdf

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4. Monocyte-bound PF4 in the pathogenesis of heparin-induced thrombocytopenia;Rauova;Blood,2010

5. Platelet transactivation by monocytes promotes thrombosis in heparin-induced thrombocytopenia;Tutwiler;Blood,2016

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