Distinct roles of mesenchymal stem and progenitor cells during the development of acute myeloid leukemia in mice-Reference-Cited by-同舟云学术

Distinct roles of mesenchymal stem and progenitor cells during the development of acute myeloid leukemia in mice

Published:2018-06-26 Issue:12 Volume:2 Page:1480-1494
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Xiao Pingnan¹^ORCID,Sandhow Lakshmi¹,Heshmati Yaser¹,Kondo Makoto¹,Bouderlique Thibault¹,Dolinska Monika¹,Johansson Anne-Sofie¹,Sigvardsson Mikael²³^ORCID,Ekblom Marja³,Walfridsson Julian¹^ORCID,Qian Hong¹^ORCID

Affiliation:

1. Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden;

2. Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden; and

3. Division of Molecular Hematology, Department of Laboratory Medicine, Lund University, Lund, Sweden

Abstract

Key Points MLL-AF9 AML cell–induced BM niche alteration is correlated with leukemia burden. Ebf2 + MSPCs participate in AML niche formation, and Ebf2+ cell depletion accelerates AML development.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/2/12/1480/881127/advances013870.pdf

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