Platelet α-granules contribute to organ-specific pathologies in a mouse model of severe malaria-Reference-Cited by-同舟云学术

Platelet α-granules contribute to organ-specific pathologies in a mouse model of severe malaria

Published:2019-12-31 Issue:1 Volume:4 Page:1-8
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Darling Thayer K.¹²^ORCID,Schenk Michael P.³,Zhou Chengjing C.⁴,Maloba Franklin M.¹,Mimche Patrice N.¹,Gibbins Jonathan M.³,Jobe Shawn M.⁵,Lamb Tracey J.¹^ORCID

Affiliation:

1. Department of Pathology, University of Utah, Salt Lake City, UT;

2. Immunology and Molecular Pathogenesis Program, Emory University Laney Graduate School, Atlanta, GA;

3. Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, Reading, United Kingdom;

4. Department of Pediatrics and Children’s Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA; and

5. Versiti Blood Research Institute, Milwaukee, WI

Abstract

Key PointsNbeal2 deficiency leads to significantly reduced lung and brain pathology and enhanced survival in a mouse model of malaria. Both antibody-dependent and antibody-independent platelet depletion in mice recapitulate the findings observed in Nbeal2−/− mice.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/4/1/1/1550576/advancesadv2019000773.pdf

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4. Delayed mortality and attenuated thrombocytopenia associated with severe malaria in urokinase- and urokinase receptor-deficient mice;Piguet;Infect Immun,2000

5. Platelets kill intraerythrocytic malarial parasites and mediate survival to infection;McMorran;Science,2009

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