Soluble interleukin-2 receptor is a sensitive diagnostic test in adult HLH-Reference-Cited by-同舟云学术

Soluble interleukin-2 receptor is a sensitive diagnostic test in adult HLH

Published:2017-12-06 Issue:26 Volume:1 Page:2529-2534
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Hayden Anna¹,Lin Molly¹,Park Sujin¹,Pudek Morris²,Schneider Marion³,Jordan Michael B.⁴⁵,Mattman Andre²,Chen Luke Y. C.¹^ORCID

Affiliation:

1. Division of Hematology, Department of Medicine, and

2. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada;

3. Division of Experimental Anesthesiology, University Hospital Ulm, Ulm, Germany; and

4. Division of Immunology and

5. Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH

Abstract

Key Points The optimal cutoff for soluble interleukin-2 receptor in this study was 2515 U/mL (sensitivity, 100%; specificity, 72.5%). sIL-2r ≤2400 U/mL is helpful for ruling out HLH (sensitivity, 100%) and >10 000 U/mL is helpful for ruling it in (specificity, 93%).

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/1/26/2529/879928/advances012310.pdf

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