High CD123 levels enhance proliferation in response to IL-3, but reduce chemotaxis by downregulating CXCR4 expression-Reference-Cited by-同舟云学术

High CD123 levels enhance proliferation in response to IL-3, but reduce chemotaxis by downregulating CXCR4 expression

Published:2017-06-20 Issue:15 Volume:1 Page:1067-1079
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Wittwer Nicole L.¹,Brumatti Gabriela²³,Marchant Ceilidh¹,Sandow Jarrod J.²³,Pudney Melanie K.¹,Dottore Mara¹,D’Andrea Richard J.¹⁴,Lopez Angel F.¹⁴,Ekert Paul G.⁵,Ramshaw Hayley S.¹⁴

Affiliation:

1. Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, SA, Australia;

2. Walter and Eliza Hall Institute, Parkville, VIC, Australia;

3. Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia;

4. Faculty of Health Sciences, School of Medicine, University of Adelaide, Adelaide, SA, Australia; and

5. Murdoch Children’s Research Institute, Parkville, VIC, Australia

Abstract

Key Points High CD123 expression increases proliferation and results in enhanced survival in response to low concentration of IL-3 in vitro. High CD123-expressing LSCs downregulate chemokine receptor expression, affecting niche interactions.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/1/15/1067/878510/advances002931.pdf

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