Acute myeloid leukemia–induced T-cell suppression can be reversed by inhibition of the MAPK pathway-Reference-Cited by-同舟云学术

Acute myeloid leukemia–induced T-cell suppression can be reversed by inhibition of the MAPK pathway

Published:2019-10-21 Issue:20 Volume:3 Page:3038-3051
ISSN:2473-9529
Container-title:Blood Advances
language:en
Short-container-title:

Author:

Moshofsky Kaycee B.¹^ORCID,Cho Hyun J.²,Wu Guanming³^ORCID,Romine Kyle A.⁴^ORCID,Newman Matthew T.¹,Kosaka Yoko²^ORCID,McWeeney Shannon K.³⁵⁶,Lind Evan F.²⁵⁷

Affiliation:

1. School of Medicine,

2. Department of Molecular Microbiology & Immunology,

3. Division of Bioinformatics & Computational Biology, Department of Medical Informatics & Clinical Epidemiology,

4. Cancer Biology Graduate Program,

5. Knight Cancer Institute,

6. Oregon Clinical & Translational Research Institute, and

7. Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR

Abstract

Key Points MEK inhibition rescues T cells from activation-induced cell death in an AML model. MEK inhibitor sensitivity is associated with inflammation pathways and PD-L1 expression.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/bloodadvances/article-pdf/3/20/3038/1496072/advancesadv2019000574.pdf

Reference54 articles.

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4. The role of targeted therapy in the management of patients with AML;Perl;Blood Adv,2017

5. Emerging therapeutic drugs for AML;Stein;Blood,2016

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