Role of altered growth factor receptor-mediated JAK2 signaling in growth and maintenance of human acute myeloid leukemia stem cells-Reference-Cited by-同舟云学术

Role of altered growth factor receptor-mediated JAK2 signaling in growth and maintenance of human acute myeloid leukemia stem cells

Published:2014-05-01 Issue:18 Volume:123 Page:2826-2837
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Cook Amy M.¹²,Li Liang¹,Ho Yinwei¹,Lin Allen¹,Li Ling¹,Stein Anthony³,Forman Stephen³,Perrotti Danilo⁴,Jove Richard⁵,Bhatia Ravi¹

Affiliation:

1. Division of Hematopoietic Stem Cell and Leukemia Research,

2. Irell and Manella Graduate School of Biological Sciences, and

3. Department of Hematology, City of Hope Cancer Center, Duarte, CA;

4. Department of Medicine, University of Maryland Medical School, Baltimore, MD; and

5. Departments of Molecular Medicine and Hematology, City of Hope Cancer Center, Duarte, CA

Abstract

Key Points JAK/STAT signaling is constitutively increased in AML stem and progenitor cells. JAK2 inhibition significantly inhibits AML but not normal stem cell growth.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/18/2826/1376532/2826.pdf

Reference35 articles.

1. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell.;Bonnet;Nat Med,1997

2. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice.;Lapidot;Nature,1994

3. Stem cell gene expression programs influence clinical outcome in human leukemia.;Eppert;Nat Med,2011

4. Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia.;Goardon;Cancer Cell,2011

5. Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2Rγc-deficient mice.;Sarry;J Clin Invest,2011

Cited by 87 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Addition of ruxolitinib and decitabine to modified busulfan/cyclophosphamide conditioning regimen for prophylaxis relapse in high-risk acute myeloid leukemia: the phase 2 prospective study;Annals of Hematology;2024-09-07

2. Biological Evaluations and Computer-Aided Approaches of Janus Kinases 2 and 3 Inhibitors for Cancer Treatment: A Review;Pharmaceutics;2024-09-04

3. Signaling pathways governing the behaviors of leukemia stem cells;Genes & Diseases;2024-03

4. Distinct roles of hematopoietic cytokines in the regulation of leukemia stem cells in murine MLL-AF9 leukemia;Stem Cell Reports;2024-01

5. Chronic inflammation promotes cancer progression as a second hit;Experimental Hematology;2023-12