Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish-Reference-Cited by-同舟云学术

Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish

Published:2014-01-16 Issue:3 Volume:123 Page:366-376
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Thompson A. A. Roger¹,Elks Philip M.¹²,Marriott Helen M.¹,Eamsamarng Suttida¹²,Higgins Kathryn R.¹,Lewis Amy¹,Williams Lynne¹,Parmar Selina¹,Shaw Gary¹,McGrath Emmet E.¹,Formenti Federico³,Van Eeden Fredericus J.²,Kinnula Vuokko L.⁴,Pugh Christopher W.⁵,Sabroe Ian¹,Dockrell David H.¹,Chilvers Edwin R.⁶,Robbins Peter A.³,Percy Melanie J.⁷,Simon M. Celeste⁸,Johnson Randall S.⁹,Renshaw Stephen A.¹²,Whyte Moira K. B.¹²,Walmsley Sarah R.¹

Affiliation:

1. Department of Infection and Immunity and

2. Medical Research Council Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield, United Kingdom;

3. Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom;

4. Pulmonary Division, Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland;

5. Nuffield Department of Clinical Medicine, Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford, United Kingdom;

6. Department of Medicine, University of Cambridge, Cambridge, United Kingdom;

7. Department of Haematology, Belfast City Hospital, Belfast, Northern Ireland, United Kingdom;

8. Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA; and

9. Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom

Abstract

Key Points Neutrophil lifespan is extended in patients with gain-of-function HIF2A mutations. HIF-2α regulates in vivo neutrophil longevity and thus tissue inflammation and repair.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/3/366/1377780/366.pdf

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